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The C677T polymorphism (NCBI SNP cluster ID rs# 1801133) in MTHFR gene results in an alanine-to-valine (A222V) substitution which in turn causes a reduction in enzyme activity and subsequent elevation of plasma homocysteine [15, 16]

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Llabani E, Hicklin RW, Lee HY, Motika SE, Crawford LA, Weerapana E, et al

FTO rs9939609, GLP1R rs6923761, and MC4R rs17782313 variants influence baseline metabolism and appetite regulation, potentially affecting both obesity severity and pancreatitis susceptibility in certain contexts

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Lowers blood sugars, in part by reducing the production of sugar in the liver