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Overall, treatment with semaglutide was associated with a reduction in the studys composite outcomecardiovascular death, nonfatal myocardial infarction or nonfatal strokeof 20% compared to a placebo, and it was linked to a safe and well-tolerated profile. SELECT trial results were published in the New England Journal of Medicine in November

The medication enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

Key points for patients: GLP-1 therapies help clear skin and reduce painful, swollen joints Obesity makes PsA harder to treat, so weight loss from GLP-1 meds helps In studies, patients on GLP-1s had fewer flares, less pain, and felt better overall

Step therapy programs may require patients to first try lower-cost medications or demonstrate unsuccessful weight-loss efforts before qualifying for GLP-1 coverage

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