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Cell Metabolism , 22(6), 956-970

However, it is encouraging that preclinical and early human studies suggest that GLP-1 agonism appears broadly protective: indeed clinical trials of these agents are being initiated in cardiovascular disease (SELECT and SOUL trials, see below), NASH, and neurodegeneration (Alzheimers and Parkinsons)

This might suggest that the early metazoan lifestyle made many of the costly steps in the biosynthesis of certain amino acids, including sulfate reduction, superfluous

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