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NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone

Lu et al., 2018)

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11 Differences exist between migraine-associated and nonmigraine CVS

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Similarly, TRP depletion does not reliably induce depressive symptoms in healthy individuals without a history of MDD [7], and mice genetically depleted of brain 5-HT did not develop depressive-like behavior [8]