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In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)

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Plant Physiol 158:340351 Cheng MC, Ko K, Chang WL, Kuo WC, Chen GH, Lin TP (2015) Increased glutathione contributes to stress tolerance and global translational changes in Arabidopsis

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