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One proposed mechanism of action is that stimulation of 5-HT 2C receptors in pro-opiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus leads to increased release of -MSH (Garfield and Heisler, 2009)

Canlorbe G, Mac G, Cortey A, Cynober E, Castaigne V, Larsen M, et al

417 In addition, low MITF/AXL ratio that indicates the phenotypic plasticity of melanoma cells is reported to determine the intrinsic response to targeted therapy

Antioxidant and anti-gout effects of orally administered zinc oxide nanoparticles in gouty mice

PMID 8876811

Several studies have reported that autophagy prevents RGC death in glaucoma animal models such as optic nerve transection and IOP elevation 24,25