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87 Alternatively, hyperexcitable small fiber neurons in PDPN might be more susceptible to bioenergetic failure, increasing distal nerve fiber degeneration

2023 NEJM)

Activation of these receptors helps coordinate satiety signaling, gastric motility, and overall energy homeostasis

In the hypothalamus, the Sel1L-HRD1 complex is indispensable for proper leptin signaling and the folding of POMC, a precursor of neuropeptides that suppress appetite and regulate energy expenditure

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Fortunately, inactive GSSG can be recycled back into the active GSH form, thanks to the glutathione reductase enzyme