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Stabilized -catenin translocates to the nucleus and binds to transcription factors such as T cell factor and lymphoid enhancing factor (TCF/LEF), thus leading to the activation of target genes

doi: 10.14283/jfa.2018.45

On the other hand, there is evidence indicating the selective permeabilization of OMM in the absence of disrupted inner membrane

PMID 23377698

doi: 10.1371/journal.pone.0226999 122 LopesFNCda CunhaNVde CamposBHFattoriVPanisCCecchiniRet al

These observations underscore the importance of altered epigenetic mechanisms in the complex pathophysiology of psoriasis and PsA (4042) and promise potential as diagnostic and/or prognostic biomarkers and future treatment targets