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RIBBON-2: a Randomized, Double-Blind, Placebo-Controlled, Phase III Trial Evaluating the Efficacy and Safety of Bevacizumab in Combination with Chemotherapy for Second-Line Treatment of Human Epidermal Growth Factor Receptor 2-negative Metastatic Breast Cancer

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 6mg/ml | 2.0ml | 0.6mg | | 12mg/ml | 1.0ml | 1.2mg | | 4mg/ml | 3.0ml | 0.4mg | **Best for:** Patients transitioning from 2mg to 4mg weekly doses

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