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These cytokines are mechanistically relevant, as activating the TNF- signaling pathway leads to hypertension, atherogenesis, vascular dysfunction, and unfavorable cardiac remodeling following MI [48], while IFN- contributes to the progression of atherosclerotic CVDs through the JAK/STAT pathway [49]

This dual-action approach is what makes it different from older GLP-1 medications like semaglutide, which target only one receptor

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You might experience multiple loose bowel movements daily during the adjustment period, then see improvement as your body adapts

Efficacy many companies, such as Eli Lilly or Zealand Pharma, are working on improving efficacy in terms of percentage weight loss or focussing on specific sub-niches, like liver diseases

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