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doi: 10.1016/S2213-8587(22)00085-7

It makes things less interesting

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Other trials showed weight loss leading to improvements in FEV1 and asthma control only [70], and similar trials showed also improvements in FEV1, FVC, and total lung capacity, but no significant improvement in airway responsiveness (i.e., airway responsiveness to inhaled methacholine

These symptoms are generally manageable, but for some, they can be severe enough to lead to discontinuation of the drug

But I twisted and did something and twisted something, which you do point out when you're picking up heavy things not to twist or bend