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The highest doses evaluated in mice were approximately 72times (males) and 105times (females) the clinical dose of 10 mg per day, based on AUC exposure

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Recent advances in Treg-based therapies highlight their promising translational prospects for clinical hepatology (56)

Maeda, S., Yanagihara, T., Inflammatory cytokines (Il-4, IL-5 and IL-13), Nippon Rinsho, 59:1894-1899 (2001)

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Interestingly, it is reported that body height associated with GH and IGF1 levels also related to cancer risk, individuals taller than 175 cm have a 20% higher risk of developing prostate cancer than those shorter than 160 cm, a 2060% higher risk of developing colorectal cancer, and have 22% higher risk of developing breast cancer (Gunnell et al., 2001