Extreme caution is advised in patients with epilepsy, advanced age, or chronic pulmonary disease because hypoxia and acidosis lower the seizure threshold and potentiate cardiotoxicity
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Therefore, it is considered a well-established biomarker of the small intestine postirradiation crypt survival, including the murine TBI model (34, 45, 46)
Overall, acne caused by skin purging often tends to appear and then disappear much faster than classic breakouts
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More frequently, the patient experiences other gastrointestinal symptoms, including gastroesophageal reflux (GERD), irritable bowels, constipation or delayed gastric emptying that causes bloating