It treats the overconsumption of food, it suppresses appetite, thats the official reason why its approved as a diet drug, amphetamine, but it also treats the underlying psychiatric condition that is often responsible for the overeating in the first place
Potential direct hepatic effects have also been identified in preclinical studies, though GLP-1 receptors are expressed at relatively low levels in the liver itself
,,LiagreA,MartiniF,AnduzeY,BoudrieH,HaverbekeOV,ValabregaS,KassirR,DebsTPetruccianiNet al.Efficacy and Drawbacks of Single-Anastomosis Duodeno-Ileal Bypass After Sleeve Gastrectomy in a Tertiary Referral Bariatric Center.2021;31(6):2691
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Interestingly, we see marginal release of cytochrome c following 5FU and a transient dip in MOMP, but no enhanced difference in sensitivity to BH3-mimetics or increase in ATF4 expression or predicted activity in RNA-seq analysis (data not shown)
They dont just suppress appetite