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Combined with the above research results, we can use these substances regulating oxidative stress as potential therapeutic drugs for KOA and verify the ability of these substances to regulate ROS in the pathogenesis of KOA in animal experiments

European Medicines Agency, Committee for Medicinal Products for Human Use (CHMP)

Vitamin d elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates toll-like receptors in human myometrial cells

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However, translating these mechanistic insights into clinical benefit is hindered by three interconnected challenges, each of which offers critical directions for future investigation

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