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Previously, single-cell RNA sequencing of mouse ovarian oocytes during the transition from the pre-follicular stage to the follicular stage indicated that follicular atresia may be associated with the ferroptosis pathway (Wang JJ

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In multi-herbal combinations, formulas containing Scrophularia radix and Panax ginseng (e.g., Isam-Tang) have demonstrated immunomodulatory and anti-apoptotic effects in experimental autoimmune thyroiditis models, alleviating thyroid inflammation and regulating proteins such as Bcl-2 and caspase-3, thereby indicating therapeutic prospects for autoimmune thyroiditis (141, 142)

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