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The teams previous studies demonstrated the anti-neuroinflammatory and blood-brain barrier stabilising effects of GLP-1RAs in rodent models, underscoring their potential neuroprotective role in stroke

These findings apply across diverse populations and are consistent across multiple large-scale trials

The double-blind trial randomized 27,564 patients with stable #ASCVD to either placebo or subcutaneous evolocumab (either 140 mg every 2 weeks or 420 mg once monthly) for a median follow-up period of 2.2 years

The salt form matters for dosing math

Conversely, POMC neurons are inhibited by NPY or ghrelin as discussed above

Received a diagnosis of gastroparesis, stomach paralysis, gastric obstruction, ileus, or intestinal pseudo-obstruction while taking these drugs or within 30 days of stopping use