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If HbA1c is relatively high, use a 2 times daily injection regimen[1]

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Zhang B, Pan C, Feng C, Yan C, Yu Y, Chen Z, Guo C, Wang X (2022) Role of mitochondrial reactive oxygen species in homeostasis regulation

For instance, superoxide dismutase downregulation was shown to be associated with inflammation in the lacrimal glands and decreased tear secretion [53], and we observed a decrease in superoxide dismutase activity in DES