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Additionally, Atg5 knockout affects steroid hormone synthesis due to cholesterol deficiency caused by impaired autophagy (Texada et al., 2019)

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DOI: 10.1210/jc.2005-1468 (PMID: 16174713) George, J.T., et al

Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]

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