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This confirms our previous finding of induction of \(\gamma\)-glutamyl cysteine ligase (GCLC) with another Nrf2 inducer, 18--glycyrrhetinic acid [71], contributing to the induction of mitochondrial catalase, HO-1, malic enzyme and glutathione handling (GST, thioredoxin reductase, GCLC)

The above is usually talked of in terms of 'anaemia', but it does show that there is a complicated link between B12, B6, folic acid, zinc and vitamin D levels, chronic disease (anaemia of chronic disease) and how the body 'manages' serum iron, ferritin, and transferrin iron saturation and keeps these in balance (or not, as in your case)

10.1111/j.1463-1326.2010.01334.x 31

Poole DP, Godfrey C, Cattaruzza F et al

Eng recognized its therapeutic potential, particularly for diabetes

Nature Communications (2021) 6