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10.1016/j.jbc.2025.110854 200 YuW.KongQ.JiangS.LiY.WangZ.MaoQ.et al (2024)

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In specific embodiments, osmolarity/osmolality of the present formulations or compositions is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of sodium salts) or the use of tonicity agents which renders the formulations or compositions endolymph-compatible and/or perilymph compatible (i.e

In recent years, small molecule antagonists, antisense oligonucleotides, and monoclonal antibodies targeting GCGR have been developed and demonstrated efficacy in improving glycemic control in both rodent models of diabetes and human patients with diabetes 8,9,10,11,12,13

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View on PubMed Goldstein AL, Hannappel E, Kleinman HK