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Esta situacin fue descrita el siglo pasado, cuando se observ que una carga de glucosa oral incrementaba los niveles de insulina, mientras que una carga parenteral (sin pasar por el tubo digestivo) no lo haca, fenmeno que hoy conocemos como efecto incretina

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Consistently, Schruf and colleagues demonstrated that inhibition of LDH5 in primary lung fibroblasts attenuated TGF-1-mediated metabolic switch to aerobic glycolysis (214)

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