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Consequently, an extracellular cystine or intracellular cysteine deficiency or inhibition of system ( SLC7A11 ) would reduce the GSH level, inhibit GSH-dependent GPX4 activity, and lead to the intracellular accumulation of L-ROS and cell death (Dolma et al., 2003

The use of reducing agents demonstrated that MTs S-thioallylation is reversible, allowing the protein to rebind Zn(II) after reduction, thereby maintaining its role in zinc homeostasis and rendering the effects of allicin temporary

Avoid taking alcoholic beverages