Monoclonal antibodies (e.g., Lpathomab) sequester LPA and has demonstrated neuroprotective effects in central nervous system (CNS) injury models by neutralizing extracellular LPA (18:1) (93), but it also shows significant cross-reactivity with more abundant lipids such as LPC and PA (94)
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Headache: Occasionally reported, usually mild
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation