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Internally, sperm mitochondria are a major source of ROS

For example, Legionella pneumophila secretes the effector SdhA, which maintains mitochondrial integrity and limits mtDNA leakage, helping the bacterium to avoid immune hyperactivation ( Beyond the cGAS-STING and NLRP3 inflammasome pathways, mtDNA also serves as a ligand for endosomal TLR9, which recognizes unmethylated CpG motifs in bacterial and mitochondrial DNA (Tripathi et al., 2023)

however, these databases are limited

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Upon winning the award, Owen said, I was driven to create a custom digital bracket system that could be done completely in the orthodontic office, allowing much faster turnaround and a much lower cost for the orthodontist