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NSAID-related gastrointestinal risks include: Dyspepsia and heartburn Gastric or duodenal ulceration Gastrointestinal bleeding or perforation Exacerbation of inflammatory bowel disease Certain patient groups face elevated risk when using NSAIDs, including older adults (over 65 years), those with previous peptic ulcer disease or gastrointestinal bleeding, patients taking corticosteroids, anticoagulants, selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), and those with Helicobacter pylori infection

10.1186/s12937-020-00559-3 26 CooperA

So, you have to pay attention to which supplements you are taking, when you take them, and how much you take

Knowing the difference between a mild skin reaction and a more serious allergic response can help ensure timely and appropriate care

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Obesity also stands as another significant risk factor