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Now we dont know if itll extend lifespan, but it does seem to do the same kind of things that metformin does, and metformin seems to have all the hallmarks of a lifespan-extending drug, so I think berberine is a good option. Sinclair notes one thing to consider: Berberine is also insoluble, so he suggests mixing it into yogurt or oil for better absorption and reduced side effects

Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review

These cytokines impair beta cell function, lowering insulin secretion (Lontchi-Yimagou 2013

The results seem to be the same for both techniques

Can I use retinol and vitamin C together