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Further in vivo studies using mice demonstrated that, while Cmp2 failed to prominently enhance glucose-mediated insulin release when compared with the more potent peptidic drugs exenatide and liraglutide, it did nevertheless significantly decrease the overall glucose excursion (Irwin et al ., 2010)

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In addition, according to the Xie and colleagues, a theoretical risk of thyroid C-cell tumors exists, based on rodent studies