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While most hydration challenges on GLP-1 therapy can be managed with increased fluid intake and dietary modifications, certain situations require prompt medical evaluation to prevent serious complications or identify underlying issues requiring treatment adjustment

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This reduces cravings and appetite and so reduces food intake/calorie intake, and also reduces blood sugar levels, which can be helpful for people with diabetes, which is what it was originally approved for

In contrast, two studies, including 41,046 exposed pregnancies and 131,407 comparator pregnancies, identified a statistically significant association with urinary congenital malformations (OR 1.24