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Notably, this upregulation occurs independently of ER stress pathways, as evidenced by the lack of activation of typical ER stress markers such as ATF4, ATF6, XBP1, and CHOP during ferroptosis

Recently, our group investigated the correlation of mRNA expression levels of GPx1 , GPx2 , GPx3 , and GPx4 and total GPx activity with the lung tissue response of thoracic irradiation using a murine model [55]

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however, this study did not assess any mitochondrial function 277

That dose, adjusted for human weight, would be roughly 1,600 mg for an average adult, far exceeding any practical use by orders of magnitude

89 The effectivity of the HAbased hydrogel could be further enhanced and used as a carrier to locally administer other novel drugs for CDLBP treatment