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Pharmacological research : the official journal of the Italian Pharmacological Society

Humane endpoints were prospectively defined prior to study initiation and included sustained anorexia, marked body weight loss, persistent gastrointestinal disturbances, or other signs of clinical deterioration compromising animal welfare

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doi:10.1111/j.1365-277X.2008.00931.x Flores-Torres MH, Christine CW, Bjornevik K, et al

Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation