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649 Although agonistic CD137 antibodies alone could not reinvigorate antitumor immunity against melanoma, CD137 agonists synergistically suppress melanoma with chemotherapy, radiotherapy, and other immunotherapy modalities including adoptive T cell therapy, ICBs, virotherapy and vaccines in mouse model and in vitro

In such cases, consulting a healthcare professional is recommended

The effectiveness of medications observed in clinical trials does not show the same results in the real world, at least due to the lower adherence of patients, discontinuation of the therapy, and the lack of representativeness in participating in clinical trials

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