To summarise, normally occurring reactive astrogliosis is in the first instance an intrinsic and evolutionary conserved set of diverse astrocyte responses that are aimed at neuroprotection, maintenance of tissue homoeostasis and preservation of nervous tissue integrity
Clinical trials of FDA-approved semaglutide and tirzepatide show average weight loss of 1521% of total body weight, far beyond what lifestyle changes alone typically achieve (individual results vary and are not guaranteed)
Patients should be aware of symptoms warranting immediate medical attention: chest pain, severe breathlessness, rapid or irregular heartbeat, or signs of heart failure (ankle swelling, persistent fatigue, breathlessness when lying flat)
Recent studies suggest GLP-1 therapies may improve pain and mobility in patients with obesity-related osteoarthritis, particularly involving the knees
This effect is usually mild and not consistent, but it can matter if you are sensitive to stress hormones
Approximately 25% of patients who undergo total gastrectomy surgery experience subsequent dumping syndrome (43)
