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Mechanistic Target: Used to observe upregulation of cellular migration, proliferation, and vascular endothelial cell differentiation

Fluorescence imaging was performed under a confocal microscope (Zeiss LSM 810, Germany or Nikon AXR, Japan), and immunohistochemistry imaging was performed under a microscope (Nikon Eclipse SI)

These effects are mild compared to other peptides and can often be minimized with proper monitoring and lifestyle support (Chen et al., 1998)