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Prions were initially identified as the causative agent in animal TSEs such as bovine spongiform encephalopathy (BSE)-- known popularly as "mad cow disease"-- and scrapie in sheep

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However, other studies have shown that Giardia -triggered apoptosis may increase IEC permeability and aid in the development of giardiasis through the action of the protease Giardipain-1 (156)

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