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Insulin signaling pathway and related molecules: Role in neurodegeneration and alzheimers disease

NLY01, an engineered Ex-4, effectively blocks the A-induced activation of the microglia and prevents the conversion of the microglia into reactive astrocytes in transgenic AD mouse models (5xFAD and 3xTg-AD) [85]

The hallmark pathologies in AD are the accumulation of amyloid-beta (A) plaques and tau tangles in the brain, leading to neuronal loss and brain atrophy [3, 4]

Subsequently, it is used as treatment for T2DM patients, as they experience insulin deficiency due to high blood glucose levels ( Garber 46)

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L., Khalid, U., et al