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40 The antioxidant properties of vitamins C (ascorbic acid), A (carotenoids and retinoids), and E (tocopherol) are known to delay or prevent oxidation and lower the concentration of free radicals in the body (de Carvalho et al., 2019)

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The absence of universally recognized data standards for wearable-derived endpoints has further complicated regulatory acceptance of digital biomarkers in pivotal trials, requiring case-by-case scientific advice meetings with the FDA's Digital Health Center of Excellence or EMA's Data Analytics Centre adding timelines and costs that partially offset DCT efficiency gains

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