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Predefined sensitivity analyses to determine potential confounding influence were conducted with the same statistical analysis set-up removing (1) patients with IIH without papilledema (IIH-WOP), and (2) patients with pre-existing migraine

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Baseline data were collected during the early follicular phase of the menstrual cycle (cycle days 17) before the start of treatment

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Six types of metabotherapy can be distinguished: supplements, stabilizers, and mimetics and/or agonists enhance beneficial effects, whereas production inhibitors, degraders and antagonists counteract detrimental effects