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Among those 22 protein complexes, we selected four, encompassing 11 of the 39 enzyme targets, for further experimental validation based upon additional criteria such as evidence from CRISPR-Cas9 screens 32,33,34 , relevance in other viral diseases, and the availability of inhibitors, as discussed below

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Sermorelin received FDA approval in 1990 as a diagnostic agent for growth hormone deficiency, and in 1997 as a therapeutic agent (under the brand name Geref) for the treatment of growth failure in children with idiopathic growth hormone deficiency

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DOI: 10.1001/jama.2010.1030