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According to the National Institute for Health and Care Excellence (NICE) guideline NG28, GLP-1 receptor agonists like Ozempic are typically recommended as part of triple therapy regimens for type 2 diabetes under specific criteria, including BMI considerations and when other treatments have not achieved glycaemic targets

SCFA-producing Bacteroides fragilis YCH46 strain (B.f.S) has also been discovered to be significantly reduced in GD patients (153)

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In addition to activating PKGI, cGMP itself contributes to smooth muscle relaxation through direct inhibition of the plasma membrane localized L-type Ca 2+ channels

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