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Thiazolidinediones have, to date, been the most effective approach [3], most likely because they reduce afterload on the beta cell and thereby decrease secretory demand and slow disease progression

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It is well-tolerated and its benefits are supported in the research

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10.1016/j.jsbmb.2009.12.005 18 BuchwaldH.EstokR.FahrbachK.BanelD.JensenM

3 Muscle is where much of our glucose (sugar) is burned for energy and stored, so losing it makes the body less sensitive to insulin (the hormone that manages our blood sugar levels)