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The rate-limiting substrate for glutathione production appears to be cysteine, hence why N-acteylcysteine has such a multitude of health benefits in clinical practice and research

Open-label extension ACCESS Participants who completed the double-blind treatment period on study drug (or placebo) and signed informed consent ( n = 151) were eligible to enroll in the ACCESS OLE to assess the longer-term safety of aleniglipron, durability and maintenance of weight loss for an additional planned 36 weeks (from weeks 36 to 72)

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it affects electrolyte transport across the intestinal mucosa and enhances colonic transport and motility