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The Food and Drug Administration granted expedited approval to orforglipron, a GLP-1 drug that works like widely used injectable medications to mimic a natural hormone that controls appetite and feelings of fullness

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5.3 Frontiers in gene-centric therapy for riboflavin pathway disorders With the rapid advancement of gene editing, viral vectors, and mRNA-based therapeutics, targeted correction of key genes in the riboflavin pathway is breaking through the limitations of traditional vitamin supplementation, offering a transformative approach for riboflavin-responsive neurometabolic disorders