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2013 Oct 18;14(10):21021-44

10.3389/fphar.2021.739615 21 ChenX.WeiW.LiY.HuangJ.CiX

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To assess whether enteric MORs also contribute to morphine-induced constipation in mice, we administered different naloxegol doses (10 mg/kg, 30 mg/kg, and 100 mg/kg, i.p.) at 2 h post morphine treatment (Supplementary Fig