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The Biden Administration initially proposed allowing Medicare to cover GLP-1 obesity drugs in Part D, but CMS decided not to proceed with broad weight-loss coverage in early 2025, citing the $40 billion over 10 years projected cost ( [65] ) ( [21] )

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[6] [7] GLP-1 is itself a naturally occurring incretin hormone produced by intestinal L-cells in response to food intake

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In the ischemia/reperfusion-induced fibrosis C57BL/6J mouse model, transcriptomic and metabolomic analyses showed that dapagliflozin treatment mitigated accumulation of tricarboxylic acid (TCA) circulating metabolites and up-regulation of inflammation in fibrotic renal cortical tissue