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211 STOPMD-3, a late-stage clinical trial investigating the efficacy of ebselen in the treatment of hearing loss and tinnitus in Mnire disease, is in progress as of May 2023

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616 ABT-639 : A peripherally acting highly selective T-type Cav3.2 calcium channel blocker

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Always increase dosages slowly and systematically based on tolerance

Therefore, the acidic residues of p53 TAD appear to have no significant impact on its interaction with the FOXO4 FHD, as these residues primarily contribute to DNA selectivity rather than binding to the FOXO4 FHD