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In summary , to treatment with GLP1-RAs compared with placebo or active controls was associated with increased risk of the composite outcome of gallbladder or biliary diseases and for cholelithiasis, cholecystitis, and biliary diseases

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The peptide also modulates inflammation by shifting macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype , reducing levels of TNF-, IL-6, and IFN- PMID: 40789979