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10.1097/YIC.0b013e32832c260b 90

The hallmarks of aging a framework established by Lpez-Otn and colleagues and updated through subsequent research include telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, cellular senescence, and dysregulated nutrient sensing, among others.1 Each hallmark represents a distinct biological failure mode

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Aberrant cell cycle progression leads to chromosomal abnormalities and embryonic arrest, making cell cycle regulation biomarkers important predictors of embryo competence [395]

for instance, H3K14 lactylation has been demonstrated to promote ferroptosis in endothelial cells exposed to lipopolysaccharide (LPS) by transcriptionally upregulating the TFRC (73)