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Data show that up to two-thirds of patients with HFpEF have CAD or coronary microvascular dysfunction including ischaemia, which leads to disruption of LV diastolic and systolic function, development of fibrosis, increased myocardial stiffness and cardiac remodelling

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Finally, our analysis supports the incorporation of GLP-1RAs in management of HFpEF, particularly in patients with comorbid obesity or diabetes as it offers a promising avenue for improving outcomes in this challenging patient population

Inflammation occurs when the body is exposed to harmful stimuli, such as pathogens, damaged cells, or irritants