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The third article is a thoughtful viewpoint where the Author comments on the importance of antioxidant defense integrity in viral infections and proposes the hypothesis that low GSH levels may have a pathogenetic role of in COVID-19, especially in the progression toward the more aggressive presentation of the disease (Polonikov, 2020)

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The enzymatic activities of these two enzymes were differentially regulated

GHK-Cu increases collagen, decorin, glycosaminoglycans, and promotes fibroblast activity in aged human skin. Pickart & Margolina, Oxidative Medicine and Cellular Longevity Antioxidant and Anti-Inflammatory Properties GHK-Cu neutralizes free radicals and protects against oxidative stress caused by environmental factors such as UV radiation and pollution

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Furthermore, a splice variant of OCTN2 that results in an insertion in the ECD leads to retention of the transporter in the endoplasmic reticulum 33